diff --git a/pkgs/development/python-modules/uamqp/default.nix b/pkgs/development/python-modules/uamqp/default.nix
deleted file mode 100644
index 89769859cdf7..000000000000
--- a/pkgs/development/python-modules/uamqp/default.nix
+++ /dev/null
@@ -1,85 +0,0 @@
-{
-  lib,
-  stdenv,
-  buildPythonPackage,
-  fetchFromGitHub,
-  fetchpatch2,
-  setuptools,
-  cython,
-  certifi,
-  cmake,
-  openssl,
-  pytestCheckHook,
-  pytest-asyncio,
-}:
-
-buildPythonPackage rec {
-  pname = "uamqp";
-  version = "1.6.11";
-  pyproject = true;
-
-  src = fetchFromGitHub {
-    owner = "Azure";
-    repo = "azure-uamqp-python";
-    tag = "v${version}";
-    hash = "sha256-HTIOHheCrvyI7DwA/UcUXk/fbesd29lvUvJ9TAeG3CE=";
-  };
-
-  patches = [
-    (fetchpatch2 {
-      name = "fix-clang16-compatibility.patch";
-      url = "https://github.com/Azure/azure-uamqp-python/commit/bd6d9ef5a8bca3873e1e66218fd09ca787b8064e.patch";
-      hash = "sha256-xtnIVjB71EPJp/QjLQWctcSDds5s6n4ut+gnvp3VMlM=";
-    })
-  ];
-
-  postPatch = lib.optionalString (stdenv.hostPlatform.isDarwin && !stdenv.hostPlatform.isx86_64) ''
-    # force darwin aarch64 to use openssl instead of applessl, removing
-    # some quirks upstream thinks they need to use openssl on macos
-    sed -i \
-      -e '/^use_openssl =/cuse_openssl = True' \
-      -e 's/\bazssl\b/ssl/' \
-      -e 's/\bazcrypto\b/crypto/' \
-      setup.py
-    sed -i \
-      -e '/#define EVP_PKEY_id/d' \
-      src/vendor/azure-uamqp-c/deps/azure-c-shared-utility/adapters/x509_openssl.c
-    sed -z -i \
-      -e 's/OpenSSL 3\nif(LINUX)/OpenSSL 3\nif(1)/' \
-      src/vendor/azure-uamqp-c/deps/azure-c-shared-utility/CMakeLists.txt
-  '';
-
-  build-system = [
-    cython
-    setuptools
-  ];
-
-  nativeBuildInputs = [
-    cmake
-  ];
-
-  buildInputs = [ openssl ];
-
-  dependencies = [ certifi ];
-
-  dontUseCmakeConfigure = true;
-
-  preCheck = ''
-    # remove src module, so tests use the installed module instead
-    rm -r uamqp
-  '';
-
-  nativeCheckInputs = [
-    pytestCheckHook
-    pytest-asyncio
-  ];
-
-  pythonImportsCheck = [ "uamqp" ];
-
-  meta = with lib; {
-    description = "AMQP 1.0 client library for Python";
-    homepage = "https://github.com/Azure/azure-uamqp-python";
-    license = licenses.mit;
-    maintainers = with maintainers; [ maxwilson ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 53133cb072aa..052edce0f572 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -777,6 +777,7 @@ mapAliases ({
   types-cryptography = throw "types-cryptography has been removed because it is obsolete since cryptography version 3.4.4."; # added 2022-05-30
   types-enum34 = throw "types-enum34 is obselete since Python 3.4"; # added 2025-02-15
   types-paramiko = throw "types-paramiko has been removed because it was unused."; # added 2022-05-30
+  uamqp = throw "'uamqp' has been removed because it is broken and unmaintained."; # added 2025-06-11
   ufoLib2 = ufolib2; # added 2024-01-07
   ukrainealarm = throw "ukrainealarm has been removed, as it has been replaced as a home-assistant dependency by uasiren."; # added 2024-01-05
   unblob-native = throw "unblob-native has been removed because its functionality is merged into unblob 25.4.14."; # Added 2025-05-02
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 17e5b711c8c6..212a9f001d90 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -18379,8 +18379,6 @@ self: super: with self; {
 
   ua-parser-rs = callPackage ../development/python-modules/ua-parser-rs { };
 
-  uamqp = callPackage ../development/python-modules/uamqp { };
-
   uarray = callPackage ../development/python-modules/uarray { };
 
   uart-devices = callPackage ../development/python-modules/uart-devices { };